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Fluorescence in situ hybridisation FISH


Fluorescence in situ hybridisation (FISH) - is a technique which involves the hybridisation of a DNA probe to a complementary sequence on chromosomal preparations to quantify sequences on chromosomal DNA. Fluorescence microscopy analysis allows for probes and targets to be visualised.

For a comprehensive review, see:

Volpil, E.V. and Bridger, J.M. (2008) FISH glossary: an overview of the fluorescence in situ hybridization technique, BioTechniques 45: 385-409 doi 10.2144/000112811